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Animal experiments All animals were treated and cared in accordance with the National Institutes of Healths guidelines for the use of experimental animals

As a pro-inflammatory steroid hormone, HA induces SLCI in the ovaries by stimulating monocyte infiltration, enhancing ROS production, and activating the NF-B pathway, which contributes to metabolic disorders in PCOS patients (141)

[DOI] [PubMed] [Google Scholar] 13.Iahtisham Ul H, Khan S, Awan KA, Iqbal MJ

Oncotarget 9(4):4496 [DOI] [PMC free article] [PubMed] [Google Scholar] Park BH, Jung KH, Son MK, Seo JH, Lee H-S, Lee J-H, Hong S-S (2013) Antitumor activity of Pulsatilla koreana extract in anaplastic thyroid cancer via apoptosis and anti-angiogenesis

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These examples show that in the presence of unrepaired DNA lesions, the classic DNA repair mechanisms can act in an aberrant manner by targeting the nondamaged DNA strand and promote genome instability