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An in vivo study on a high fat diet enriched with glutamine administered to Wistar rats found that glucose uptake increased with stimulation of insulin signaling in skeletal muscles and reduced hepatic gluconeogenesis, which both showed improvement in insulin sensitivity [43]

Not only does this result in reduced availability of NO for vasodilation, but ROS and RNS can also induce the proliferation of smooth muscle cells and stimulate the expression of cell adhesion molecules, mostly ICAM-1 and VCAM-1, that control the inflammation on the vascular level by leukocyte migration and adhesion [52]

Antioxidant and antiradical activities of L-carnitine

10.1016/j.brainres.2011.04.028 Brain Res

Am J Prev Cardiol