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In addition to the absence of cytologic atypia and conspicuous mitotic activity, the dermal component demonstrates zonal maturation as the melanocytes become smaller and more spindled (instead of epithelioid) and lose cytoplasmic pigment (in cases with superficial heavy pigmentation) with descent into the deep dermis/submucosa

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[41] Several other early studies have argued against the theory that the production of toxin has anything to deal with stress or catabolite repression of either toxin TcdA or TcdB