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Mitochondria as a pharmacological target: Magnum overview

Liu M, Zhang L, Zhong M, Long Y, Yang W, Liu T, et al

Others can't take it because they're planning a pregnancy or have certain health conditions

2 B12 deficiency can be due to inadequate dietary intake, in particular in people following a strict vegan diet (B12 is only found in animal foods)

[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Amic F., Drmic D., Bilic Z., Krezic I., Zizek H., Peklic M., Klicek R., Pajtak A., Amic E., Vidovic T., et al

Moreover, senescent immune cells of various organs release pro-inflammatory cytokines (for example tumor necrosis factor (TNF-), interleukin 1 (IL-1) and IL-6), chemokines or matrix metalloproteinases, which contribute to the development of a rather pro-inflammatory phenotype, the so-called senescence-associated secretory phenotype (SASP), causing DNA damage and a state of chronic systemic lowgrade inflammation [8, 16, 25,26,27,28,29]