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The SM protocol produced HLCs with the morphological appearance of established liver tumor derived cell lines (Figure 2B

After the tumors reached about 100 mm 3 , the mice were randomly distributed into 7 groups ( n = 5) (G1-G7: Saline, PS-CHO + L, ATRA-SS-ATRA, PS-CHO@ATRA-SS-ATRA, PS-CHO@HA-DSPE-PEG2000 + L, PS-CHO@ATRA-SS-ATRA + L and PS-CHO@HA-ATRA-SS-ATRA + L, 5 mg/kg), and then all groups were intravenously injected for three times on day 0, 3, and 6

Acknowledgments The authors thank the members of the Department of Anesthesia and Pain Medicine at the Hospital for Sick Children (Toronto, Ontario, Canada) for the protection of research time for the study investigators

It lends considerable scientific weight to the micro-dosing strategy for BPC-157

Cholesterol descriptive statistics (zero, three, and six months)

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