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Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimers models

Magnetofection PEI-MNPs, T0-CRISPR/Cas9-PEI-MNPs, and T3-CRISPR/Cas9-PEI-MNPs (2 g DNA/well) were incubated with cultured cells in serum free media for 30 min followed by addition of 10% FBS

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Interestingly, AMD3100 reversed this benefit, producing a 55% increase in nitrotyrosine compared to DOX + GHRP-6, further implicating CXCR4 in regulating oxidative stress