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Gut microbiota can produce or alter bile acids (BAs) and short-chain fatty acids (SCFAs), which have important immune and inflammatory functions

We integrate these mechanisms with endothelial dysfunction, innate immune priming, ECM remodeling and barrier failure across cardiovascular, metabolic, neurodegenerative, oncologic, pulmonary, renal and critical-illness contexts, emphasizing crosstalk with RNS/RSS and iron metabolism as key modulators
