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[DOI] [Google Scholar] 36.Fuglie L.J

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Folic acid is synthetic and must be converted: With MTHFR variants or high intake, unmetabolized folic acid can accumulate, and the clinical significance is still being studied

To overcome these limitations, we advocate for a paradigm shift towards precision medicine

The regulation of HIFs is just one example of how ROS and cellular ratios of various TCA cycle metabolites, i.e., mitochondrial metabolism, can control gene expression and cellular responses (39)

Cysteine sulfenylation directs IRE-1 to activate the SKN-1/Nrf2 antioxidant response