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NO can be toxic through combination with superoxide to generate peroxynitrites leading to nitration of biomolecules, altering their structure and function

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Oh P, Lobry C, Gao J, Tikhonova A, Loizou E, Manet J, van Handel B, Ibrahim, S., Greve, J., Mikkola, H., Artavanis-Tsakonas, S., and Aifantis, I., "In vivo mapping of Notch pathway activity in normal and stress hematopoiesis", Cell Stem Cell 13: (2013)

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But, whether or not to use them should depend on what each patient needs and what the doctor says