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Description
The hydroxy and methyl groups of the isohexenyl side chain of the shikonin tail form hydrogen bonds with R188 and Q189, respectively, in the S3 subsite

Because of this mechanism, a mutation in the gene encoding 4-Maleylacetoacetate isomerase is not considered dangerous

A follow-up study in 2007 found significant dose-related increases in malignant tumors in some of the rats

[DOI] [PubMed] [Google Scholar] 2.Lauder J.M

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