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173 Meta-analyses of controlled trials have found agomelatine is similar in efficacy to other antidepressant drugs, but is more tolerable than most, mainly due to its lower likelihood of causing sexual side effects and weight gain

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The multifunctionality of GPX and GST exemplifies this dual role, bridging ROS metabolism with secondary metabolic pathways and stress signaling networks

This mechanism establishes OLA as a promising anti-fibrotic therapeutic candidate ( Mitochondria-targeted antioxidants or CYP2E1 inhibition prevents this toxicity, highlighting CcO dysfunction as a key pathological mechanism ( Daphnia magna through its reactive metabolite NAPQI