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Vlasits J, Jakopitsch C, Schwanninger M (2007) Hydrogen peroxide oxidation by catalase-peroxidase follows a non-scrambling mechanism

Baseline melasma severity was determined based on the dermatologists clinical evaluation of melasma lesions and also based on mMASI score calculation at the first dermatology visit before treatment initiation

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Its effectiveness may depend on: Dose Duration of use Product quality Baseline glutathione status Digestive and metabolic differences The outcome being measured Increasing a glutathione laboratory measurement does not automatically establish a clinical benefit, but the evidence does challenge the absolute claim that ordinary oral glutathione cannot be absorbed or used