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As acute pancreatitis resulted in severe oxidative modification of proteins, an intensive increase (roughly 70%) in the content of 2,4-dinitrophenylhydrazine (DNPH)-reactive protein carbonyls was obtained in the cerulein-induced pancreatic tissue (0.2301 U/mg 0.02078) when compared to that of the non-cerulein-treated control (0.1321 U/mg 0.00925)

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Therefore, the second generation of TPO molecules-TPO receptor agonists (TPO-RAs) without immunogenicity-such as romiplostim, eltrombopag and avatrombopag, were developed one after another

53 Obesity The pathological expansion of adipose tissue is specifically manifested in the dysregulated production of adipokines and lipid, low-grade inflammation and enrichment of extracellular matrix

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