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Iran J Immunol 11 : 200209

Glycolytic ATP generation was inhibited by incubating the parasites in glucose-free HBS buffer plus 5 mM 2-deoxy-D-glucose, a competitor with glucose for hexokinase binding, and 5 mM sodium pyruvate [40]

Mittal (55) and others compared mice with overexpression or knockout of the TWEAK gene and found that skeletal muscle atrophy and fast muscle fibers increased significantly after 4 to 5 months of overexpression, with increased Fn14 expression level and the opposite finding in the knockout group

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2) NLRP3 inflammasome activation, triggered by Tat, gp120, and viral RNAs, which is exacerbated by ROS, ion flux changes, and impaired autophagy, with NF-B acting as a crucial priming signal for pyroptosis and pro-inflammatory cytokine release

274,275 Notably, -amyloid peptides interact with these GLUTs, promoting their internalization and reducing glucose transport efficiency, 276,277 which is considered a key factor in metabolic dysregulation