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D3 has inner ring deiodinase activity and degrades T4 to rT3 and T3 to 3,3-T2

Comp Biochem Physiol A Mol Integr Physiol (2004) 138(4):4359.10.1016/j.cbpb.2004.06.003 8 HuleihelMLunenfeldE

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IGF-1 stimulates retinal vessel growth, and the CHMP cited this concern as one reason the European application was not approved

While chaA encodes a characterized Na + (Ca 2+ )/H + antiporter, chaB and chaC were originally identified as putative, though uncharacterized, regulators of chaA (Oshima et al., 1996)