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A leaky gut may be an initial event in the pathogenesis of inflammatory bowel disorders, allowing bacteria-derived molecules into the mucosa and flaring up uncontrollable inflammatory signal cascades

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The volume determines the concentration of the final solution

9 Other research has suggested that elevated vitamin B12 levels may occur as part of the disease process itself

We know that B12 recovery from bile would be a problem but this only contributes 5mcg to the picture, so I think its an open question