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Our previous results showed that the light cycle phase advance as a model for jet lag and sleep loss led to lacrimal gland function impairment and disturbance of tear secretion rhythm in mice (Huang et al., 2022a

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In both of our studies, CRISPRi demonstrated its highest level of effectiveness and exhibited optimal performance in targeting its specific genes and its related mechanisms, hence manifesting its lead role in biofilm-induced infections like urinary tract infections (UTI)

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This typically lasts 5-15 minutes and is considered a normal physiological response rather than a concerning side effect