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Description
Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1

Ther Deliv 3:961979
HampelHO'BryantSEMolinuevoJLZetterbergHMastersCLListaSet al

Pregnancy, breastfeeding, kidney disease, severe anemia, and neurologic symptoms may require closer follow-up

Nearly 4% of users who reported side effects also described reproductive symptoms, including irregular menstrual cycles, intermenstrual bleeding, and heavy bleeding
from injection to oral, more frequent monitoring may be needed until baseline levels are achieved
