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Notley SR, Akerman AP, Friesen BJ, Poirier MP, Sigal RJ, Flouris AD, Boulay P, McCourt E, Ruzicka M, Kenny GP

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selective inhibition of heparan sulphate and not chondroitin sulphate biosynthesis by a small, soluble competitive inhibitor

After a comparison with the known IRAP structures and a combination with small angle X-ray scattering experiments it was proposed that IRAP is an open dimer in solution and assumes a more compact conformation upon HA08 binding