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By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1)

Because the body is efficient at excreting excess B12 through urine, there is no established tolerable upper intake level (UL) for the vitamin

Authors' Contributions Liu JR, Deng ZH, Zhu XJ, Zeng YR, Guan XX, and Li JH contributed to this paper

Liver, clams, oysters, nutritional yeast, salmon, tuna, and ground beef are all very high in vitamin B12

These findings reinforce the role of IGF-1 in glucose homeostasis