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These approaches may better reflect changes in metabolite concentrations (Cajka & Fiehn, 2016)

doi: 10.38212/2224-6614.3474 447 ChenCMWuCCKimYHsuWYTsaiYCChiuSL

We employ validated lysis protocols using specific detergents (e.g., Triton X-100) or organic solvents (e.g., methanol, acetonitrile) that are compatible with the downstream analytical method
