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In patients with creatinine clearances between 45 mL/min and 79 mL/min, modify administration of ibuprofen as follows [see Warnings and Precautions (5.6), Drug Interactions (7) and Clinical Pharmacology (12.3)] : Obtain complete blood count on Days 1, 8, and 15 of each cycle

Why is the effect of MNA treatment in vivo not as good as it should be in the control of fasting blood glucose, HbA1c, and body weight