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doi:10.1046/j.1365-2958.1999.01593.x
Possible risks include allergic reaction, local irritation, or unknown long term effects

Both of those have been shown to be effective ways to manage weight

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One study investigated DNA methylation levels in males following one night of sleep deprivation (Cedernaes et al., CLOCK ), cryptochrome circadian clock 1 ( CRY1 ), brain and muscle ARNT-like 1 ( BMAL1 ) and period circadian clock 1 ( PER1 )

[315] The increased use of CT scans has also increased patients' exposure to x-rays, a type of ionizing radiation that contributes to the development of cancer