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These down-regulate the C-C Motif Chemokine Ligand (CCL)20 and CCL22 expression and their receptors in EAE mice, inhibiting the leukocytes infiltration into the CNS, an essential step in the MS pathogenesis, and improving the clinical symptoms, and the pathological scores of disease (Jafarzadeh et al., 2014, 2015, 2017)

Nat Commun 9:4230

Chronic high-dose vitamin B intake (generally in gram quantities daily over many months) has been linked to severe sensory neuropathy characterized by numbness, impaired proprioception, and paresthesia in a stocking-glove distribution

Both compounds can independently cause GI discomfort, making symptom attribution difficult if started simultaneously

Motawea MH, Elmaksoud HAA, Elharrif MG, Desoky AAE, Ibrahimi A