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2 Materials and methods 2.1 Study design This study was a multi-center, prospective, double-blind, randomized clinical trial aimed to assess the absorption rate and hence bioavailibility of an innovative oral Sucrosomial B12 (Sidevit B12 developed by Pharmanutra S.p.A, Pisa, Italy) in enhancing circulatory B12 levels in healthy deficient adults, compared to various conventional oral B12 supplement formulations, selected randomly from local pharmacies at each participating center

This is a preliminary finding requiring further study

Subsequently, SAH is converted to Hcy by SAH hydrolase (SAHase) (Okamoto et al., 2003

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In this step, genetic disorder prevents necessary metabolic processes from taking place in cells (Hakami et al., 1971) (Fig

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