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Additionally, the enzyme lipoxygenase (LOX) facilitates the peroxidation of PUFAs, and decreasing LOX expression has been shown to mitigate ferroptosis, particularly that induced by erastin (40, 42)

Metabolic substrates, cellular energy production, and the regulation of proximal tubular transport

By activating the transcription factor XBP1, IRE1 orchestrates an adaptive program that enhances protein folding and disposal capacity within the ER (98)

(2020) 217:e20191247

Immunologic findings in two female patients suffering from a rare clinical entity - hereditary eosinophilia associated with intraepidermal bullous dermatitis and subacute sclerosing panenciphalitis - were examined

The study showed that metabolically active and apoptosis-resistant fibrotic regions in IPF patients and mouse models exhibited low expression of AMP-activated protein kinase (AMPK)