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In vitro, TNF and IFNs can block collagen synthesis and extracellular matrix formation and thus inhibit the formation of capillary-like structures [281, 282]

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Clinically approved anti-angiogenic agents predominantly target the VEGF pathway, which is a key regulator of pathological angiogenesis due to its mitogenic and chemotactic effects on endothelial cells (8082)

10.1016/j.tips.2016.12.004 93 RussoE

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