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Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age

This is not unique to retatrutide

The early human evidence is suggestive

A study in the Journal of Clinical Endocrinology and Metabolism found that combined GH and testosterone administration in older men produced greater improvements in lean body mass and fat reduction than either hormone alone (Giannoulis et al., 2006)

Again, different amino acid sequences, all designed to achieve the same thing, which is more growth hormone

The path forward for cortistatin likely requires development of selective analogs with improved pharmacokinetics and a clinically feasible administration route