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Beta-3 adrenergic receptors can desensitise under chronic agonist exposure, a phenomenon documented in the context of other beta-adrenergic agonists

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(There are several studies involving animals, but not human subjects.) What research does show is that people who are overweight tend to be low in vitamin B12

We strongly recommend it, but no - you do not have to have one if you choose not to, though we do explain why this is storngly recommended