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Chirality 23, 891896

Studies indicate that osteocalcin mediates between bones and the pancreas in regulating glycemic status, promoting the proliferation of cells and insulin secretion through actions in the pancreas and adipocytes

doi: 10.3390/medicines6030079

The effect could be reverted by GSH treatment but not DTT, possibly suggesting that it is linked to a requirement for GSH in biosyntheses rather than mediated via redox changes (Schlaeppi et al., 2008)

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With regard to tGSH levels (a) no significant change was observed in old versus young adults (Pardo-Andreu et al., 2006), but (b) a decrease with age was reported in old adult sub-groups (ages 6066, 7278, 8187 and 90 yrs) (Prez et al., 2020)
