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Activation of the IL-6/Nox2 pathway in schizophrenia leads to the loss of the GABAergic phenotype of PV interneurons and decreased inhibitory activity in the prefrontal cortex [53] Inflammatory cytokines can affect the synthesis of monoamine neurotransmitters

26 , 28 Certain autoimmune conditions may also feature POTS-like symptoms, further complicating the diagnosis and signifying an important autoimmune parallel

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Redox signaling involved in nutrient-sensing mechanisms The nutrient-sensing network is integral to how cells perceive and respond to their nutritional environment, directly impacting pathologic processes

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I., Irizarry, R