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Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (bptes) analogs as glutaminase inhibitors

For the wt PV2-CP17 structure, the atomic coordinates of PV2 Lansing strain (PDB ID 1EAH) 47 were used and a similar procedure was applied to optimise the initial fit

These results have also been confirmed by single molecule fluorescence studies which has revealed that a slight excess of protons in the solution is conducive towards aggregation of monomeric -synuclein (Trexler and Rhoades, 2010)

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