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doi: 10.3390/ijms23137267

The importance of reducing Cys274/Cys276 in DnaJb5 for interaction with HDAC4 has been emphasized, as has the impact of decreasing Cys667/Cys669 in HDAC4 on preventing its nuclear export

The most well-established mechanisms include through (1) NF-B inhibition, (2) suppression of STING signaling, (3) interference of pro-inflammatory cytokine transcription, and (4) through NRF2 target gene signaling pathways

In this study, we focused on the effect of 5-HT on the APAP-induced hepatotoxicity and the relevant mechanisms in mice models