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This can be exacerbated by high toxin levels

Selenium metabolites in urine: a critical overview of past work and current status

doi: 10.1371/journal.pgen.0030005 86 SinghSLiSS-L

Interestingly, the analysis found that short-term treatment (90 days or fewer) appeared more effective than longer-term treatment for certain lipid markers, possibly due to metabolic adaptation with extended use