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These include potential immunogenicity, undefined long-term biosafety profiles of novel nanomaterials, suboptimal drug loading/release kinetics, limited penetration into the invasive tumor margin, and overcoming the immunosuppressive/hypoxic/acidic TME
doi: 10.1007/s10787-015-0232-5 PMID: 26002695 Chiu YM, Chen DY (2020): Infection risk in patients undergoing treatment for inflammatory arthritis: non-biologics versus biologics

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