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[152], showing that a TLR9 agonist (CpG oligodeoxynucleotides) modulates immune responses and reduces amyloid burden in transgenic AD mouse models, although effects on cognition and plaque clearance appear context-dependent

Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration

10.1038/srep22831 209 LiaoB.ZhaoW.BeersD

Melatonin improves rate of monospermic fertilization and early embryo development in a bovine IVF system

Sci Transl Med 2020;12:eaay0167

126,127 and (4) increased energy consumption due to increased gluconeogenesis, which is an energy-intensive process that costs ~400600 Kcal/day and the thermic effect of protein, which has the highest energy cost among all the three macronutrients (Fig