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There is no doubt than even unexpired opened vials deteriorate over time

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Schmidt S, Jrgensen M, Chen Y, Nielsen R, Sandelin A, Mandrup S

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During the last three decades, a variety of different studies on bioactive peptides that are opioid receptor ligands, have been carried out, with regard to their isolation and identification, as well as their molecular functions in living organisms