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Transgenic expression of TIN2 unable to bind TRF1 suggested that full TIN2 recruitment to telomeres requires TRF1 46

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Molecular modeling and laboratory studies conducted over the past two decades suggest that the AEDG sequence can bind to chromatin structures , influencing gene expression associated with aging and cellular regulation

In another study, it was shown that Epitalon had an effect on macrophages depending on the age of mice from which the cells were collected

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