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Alpert MA, Bauer JH

To potentially prevent or slow down LA fragmentation by the brush-border enzymes responsible for LA fragmentation, chiral modification of the entire LA sequence to all D amino acids was conducted, which resulted in the generation of LA Analog 6 (A6) by Innovate Biopharmaceuticals, Inc

The highest monotherapy dose studied is 4.5 mg per week (Lancet 2021 Phase 2)

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Sohail R., Mathew M., Patel K.K., Reddy S.A., Haider Z., Naria M., Habib A., Abdin Z.U., Chaudry W.R., Akbar A

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