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The therapeutic effects of hydrogen on these conditions are closely linked to its antioxidant, anti-inflammatory, and anti-apoptotic properties, which collectively contribute to its therapeutic potential

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This systemic approach differs fundamentally from pharmaceutical interventions that target single pathways

Presumably, OTC-dependent increases in intracellular thiols improve cellular antioxidant defenses in the absence of GPx1

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Gastroenterology 134 , 11591168, doi: 10.1053/j.gastro.2008.01.011 (2008)