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doi: 10.1016/j.redox.2019.101255 [DOI] [PMC free article] [PubMed] [Google Scholar] 379

Remarkably, the degree of improvement when TB4 was administered systemically through intraperitoneal injections or only locally within the cardiac infarct was not statistically different, suggesting the beneficial effects of TB4 likely occurred through a direct effect on cardiac cells rather than through an extracardiac source [87]

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After stimulation, action through the NO system shows the high output of NO from iNOS acting in antimicrobial, antiviral, antiparasitic and tumoricidal processes and the cytotoxic effect of NO involved in immunological and tissue-damaging actions (for a review, see [100])