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Since there is limited knowledge about pre-MM lesions and a lack of corresponding molecular pathological biomarkers, early diagnosis, as well as early intervention becomes extremely challenging, leading to the short life expectancy in MM patients

Experimental complications may also contribute to lack of data granule proteins may be highly sensitive to changes in structure induced by the addition of a tag (Uebel and Phillips 2019)

Also, laboratories are burdened by a large volume of patients attending for tests in the morning

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