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human efficacy is unproven [3] [4]

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The systemic release of reactive oxygen species (ROS), proinflammatory cytokines, and other mediators amplifies multi-organ injury, leading to increased morbidity and mortality in various clinical contexts, including surgery, trauma, and vascular diseases [5,6]

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Today 2020, 37 , 112 125, DOI: 10.1016/j.mattod.2020.02.001Google Scholar17Overcoming blood-brain barrier transport: Advances in nanoparticle-based drug delivery strategiesDing, Shichao

At very high concentrations, it may inhibit monoamine oxidase slightly, but this effect is not clinically relevant at typical doses