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Supplementary data Supplementary data are available at European Heart Journal online

These symptoms typically occur during dose escalation and often diminish over time

Nicholls SJ, Bhatt DL, Buse JB, Del Prato S, Kahn SE, Lincoff AM, McGuire DK, Nauck MA, Nissen SE, Sattar N, Zinman B, Zoungas S, Basile J, Bartee A, Miller D, Nishiyama H, Pavo I, Weerakkody G, Wiese RJ, DAlessio DA, SURPASS-CVOT Investigators (2024) SURPASS-CVOT Investigators

Medial nucleus tractus solitaries (mNTS) and area postrema (AP) The NTS is a series of sensory nuclei in the mammalian brainstem

In both studies no difference was seen in normal vs renally impaired subjects
