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(2019) 92:e203850

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Different optical stereoisomeric forms (3S-3S, 3R-3S, 3R-3R) and geometric isomeric forms (Z and E isomers) demonstrate varying effects [6]

Specifically, certain miRNAs can target and regulate iron metabolism-related proteins or directly inhibit the expression of System Xc and GPX4, thereby promoting ferroptosis (Xu et al., 2021)

In 2014, Wang et al

GPX4 Inhibitors Induce Ferroptosis Other ferroptosis inducers directly target glutathione peroxidase 4 (GPX4), a lipid repair enzyme downstream of GSH that works to limit lipid peroxide accumulation ( Figure 3 )