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The pivotal trial, published in the New England Journal of Medicine , randomly assigned 412 patients with HIV, 86% of whom were men and all of whom had abdominal fat accumulation, to receive a daily subcutaneous injection of either 2 mg of tesamorelin or placebo for 26 weeks, with the primary endpoint being percent change in visceral adipose tissue as measured by CT scan

10.3389/fncel.2018.00313 [DOI] [PMC free article] [PubMed] [Google Scholar] 111.Lopez-Barbosa N, Garcia JG, Cifuentes J, Castro LM, Vargas F, Ostos C, et al