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The Metabolic Profile of LSCs Drives Drug Resistance AML is a clonal disorder of haematopoiesis in which normal HSCs or multipotent progenitors acquire genetic mutations that result in dysregulated self-renewal ability ( Figure 1 )

Delayed gastric emptying extends the time B12 spends in the acidic stomach environment, which might initially seem beneficial

Selenite is effective in inhibiting the proliferation of a wide range of cancer cells, and it has been shown to exert anticancer activity in a variety of cancer cell lines, including prostate, breast, lung, liver, bladder and osteosarcoma (210)

A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia, and significant resistance to experimental diabetes

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