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Although sperm DNA is highly compacted by protamines, certain regions (such as the nuclear matrix attachment regions) remain relatively loose, and sperm rely on limited 8-oxoguanine DNA glycosylase (OGG1) for repair (95)

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The animals included in the present study were shown to display a dramatic testicular damage manifested by a variety of histopathological abnormalities which include a reduction of testicular size, congestion and severe edema, alterations in tubular diameters, complete loss of the germinal line and total reduction of cellular proliferation as it has been previously reported [1517]