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However, co-IP experiments with SPOC domains or full-length proteins show that DIDO may have a similar or even stronger affinity for Pol II in cells, which may be due to higher expression levels and stability compared to PHF3 (Fig

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At the same time, it exhibits a favorable safety profile in animal studies

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Mei Y, Monteiro P, Zhou Y, Kim J-A, Gao X, Fu Z, et al

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