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Even moderate amounts significantly worsen nighttime reflux
Abnormal blood lactate accumulation during repeated exercise testing in myalgic encephalomyelitis/chronic fatigue syndrome
10.3896/ibra.1.53.1.12 225 PengY.ZongY.WangD.ChenJ.ChenZ.-S.PengF.et al (2023)
Pull back the plunger and draw up the prescribed dose of medicine, plus a little more
10.1038/s41467-022-35720-5 157 SongJ
This means a lower and less predictable amount of the active compound might reach systemic circulation, potentially requiring higher doses and introducing variability into research findings
